Active Trials

These COVID-19 clinical trials are active and approved by Health Canada. Many more are pending approval and will be added in the days and weeks ahead.

Help us complete the circle. Add your trial to our list of active COVID-19 Canadian clinical trials and gain access to a wider participant registry.

Trial name A Randomized, Open-Label Trial of CONvalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness (CONCOR-1)
Type of trial Phase III
Trial ID NCT04348656
Health Canada Status Health Canada approved
Trial Status Open
Location
Ontario, Alberta, British Columbia, Manitoba, New Brunswick, Newfoundland and Labrador, Nova Scotia, Prince Edward Island, Quebec, Saskatchewan, Northwest Territories, Nunavut, Yukon
Trial description

CONCOR-1 Trial Description: A Randomized, Open-Label Trial of CONvalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness. This is a prospective randomized control trial that is comparing convalescent plasma to standard of care in adult patients admitted to Canadian hospitals with respiratory complications from COVID-19. Intervention will be 500 mL of convalescent plasma from donors with SAR-CoV-2 neutralizing antibodies in addition to standard of care. We are not yet enrolling patients. There will be between 40-60 sites participating across Canada.

Study team
Donald Arnold
Donald Arnold
MD
Hamilton Health Sciences Centre
Trial name ALBERTA HOPE COVID-19 for the Prevention of Severe COVID19 Disease
Type of trial Phase III
Trial ID NCT04329611
Health Canada Status Does not require Health Canada approval
Trial Status Open
Location
Alberta
Trial description

Albertans with COVID-19 are at risk of deteriorating and developing severe illness. Those over age 40 or with co-morbid illness, and likely those who are immune suppressed, are at highest risk. This study will include a focus on people with immune-suppressed states. Individuals confirmed to have SARS-CoV-2 infection will be identified using administrative data (positive lab result, age 18 or over, not hospitalized, and not living in SL4 level of care). They will then be contacted by AHS staff, independent of the researchers, to obtain their consent for the researchers to contact them about this trial. The AHS staff member who contacts the individual will enroll consenting individuals into a study database. If they provided an email address an email will automatically be sent to the individual with study information. Those who decline to be contacted will also be informed of the study website so they can choose to review the study information and self-enrol, although they will need to do so quickly to meet study timelines. Enrolled participants will be contacted by a study coordinator. Those without access to the internet will be informed about the study details when they are contacted by a study coordinator. When the study coordinator contacts potential participants the study will be reviewed, and the potential participant will have an opportunity to ask questions. Consent for participation will be obtained by telephone. Telephone consent will be recorded. Participants will then be screened for inclusion and exclusion criteria by telephone interview and review of Alberta Netcare. Alberta Netcare is the province of Alberta's public Electronic Health Record used to store patient information so that it is easily accessible to healthcare professionals for the purpose of care. Information like immunizations, ECG results, diagnostic images and reports, written medical reports (e.g. surgery reports, consultations, hospital admissions), diagnostic lab testing results (e.g. blood tests, urine tests, blood bank info), allergies and intolerances (drug and food allergies, food intolerances), prescription history, and general patient information (e.g. name, birthdate, personal health number, address, phone number). Those who are not eligible for the study will be informed of the reason(s) for ineligibility (generally it will be a safety exclusion and they should be aware of this). Those who are eligible will be randomized to receive HCQ or placebo for a total duration of 5 days. Study drug will be delivered to their residence by courier. Telephone follow-up will occur at day 7 (range 7-10 days) and at day 30 (range 25-35 days).

Study team
luanne metz
Dr. Luanne Metz
MD
University of Calgory
Michael Hill
Dr. Michael Hill
MD
University of Calgory
Trial name Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19
Type of trial Phase II
Trial ID NCT 04315298
Health Canada Status Does not require Health Canada approval
Trial Status Open
Location
United States, Alberta, British Columbia, Manitoba, New Brunswick, Newfoundland and Labrador, Nova Scotia, Ontario, Prince Edward Island, Quebec, Saskatchewan, Northwest Territories, Nunavut, Yukon
Trial description

The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with COVID-19 regardless of severity strata. (This initiative also has pan-Canadian sites.)

Study team
Trial name IMPACT: IMPact of Antimalarials on Covid-19 Infections in RAPPORT
Type of trial Not Applicable
Trial ID NCT04347798
Health Canada Status Does not require Health Canada approval
Trial Status Open
Location
Alberta
Trial description

This study aims to evaluate the experience of Alberta patients with inflammatory arthritis who participate in the the RAPPORT-ONTRAAC registry during the COVID-19 pandemic, specifically comparing the experience of those taking anti-malarial medications compared to those who do not. This registry includes approximately 2500 northern Alberta patients with inflammatory arthritis who receive highly complex therapies which may be associated with side effects. This program of data collection and research has been evaluating the effectiveness and safety as well as associated health care costs of rheumatoid and psoriatic arthritis patients since 2004. The principle investigators are based at the University of Alberta while the co-investigators are academic rheumatologists at the University of Alberta. The registry has approximately 900 patients taking anti-malarials combined with their complex therapies and ~ 1500 not on anti-malarials in combination with their complex therapies. We aim to perform a case control study evaluating the impact of anti-malarial drugs (eg. hydroxychloroquine and chloroquine) on the development of COVID-19 compared to those patients who are not on anti-malarial drugs over the next 6-12 months. In addition to frequent e-mail surveys screening for the clinical symptoms of COVID-19 and understanding their concomitant arthritis medication use, we will compare the healthcare outcomes of both groups of arthritis patients with and without COVID-19 for the duration of the pandemic. This information will provide critical information beyond an anecdotal level on whether or not anti-malarials truly provide a protective benefit against COVID-19 or reduce the severity of infection. A blood sample from all participants (Covid-19 positive and negative) will be drawn approximately six months into the study for measurement of antibodies to Covid-19 and possible blood types and HLA alleles. Additionally, this study will be linked to another study "Persistence of SARS-Cov2 in immunocompromised patients" which will specifically evaluate COVID-19 serology and nasopharyngeal swab findings in the subset of patients who develop COVID-19.

Study team
Stephanie
Dr. Stephanie Keeling
MD
University of Alberta
Walter
Dr. Walter Maksymowych
MD
University of Alberta
Trial name Post-exposure Prophylaxis (PEP) or Preemptive Therapy for COVID-19: A Pragmatic Randomized Clinical Trial
Type of trial Phase III
Trial ID NCT 04308668
Health Canada Status Health Canada approved
Trial Status Open
Location
Quebec, Manitoba, Alberta, Ontario
Trial description

This study is to test if post-exposure prophylaxis with hydroxychloroquine can prevent symptomatic COVID-19 disease after known exposure to the SARS-CoV-2 coronavirus, as well as if early preemptive hydroxychloroquine therapy can prevent disease progression in persons with known symptomatic COVID-19 disease, decreasing hospitalizations and symptom severity.

Study team
Todd C. Lee
Todd C. Lee, MD, MPH, FIDSA
Associate Professor in the Department of Medicine
McGill University
Ryan Zarychanski
Ryan Zarychanski
MD
University of Manitoba
Lauren E. Kelly
Lauren E. Kelly, PhD, MSc, CCRP
Clinical Trialist and Certified Clinical Research Professional with SoCRA
Organization
IIan Schwartz
IIan Schwartz
MD
University of Alberta
Emily McDonald
Emily McDonald, MD, MSc, FRCPC
Assistant Professor of Medicine
Organization
Dr. Zain Chagla
Dr. Zain Chagla
MD MSc FRCPC DTMH
McMaster University
Trial name Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (REMAP-CAP)M)
Type of trial Phase IV
Trial ID NCT 02735707
Health Canada Status Health Canada pending
Trial Status Open
Location
Ontario, Alberta, Manitoba, Quebec
Trial description

The purpose of this study is to evaluate the effect of a range of interventions to improve outcome ofon patients admitted to intensive care with community-acquired pneumonia. In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic resulting in critical illness.

Study team
John Marshall
John Marshall
MD
Director, Critical Care Research, St. Michael’s Hospital, Unity Health
Srinivas Murthy
Srinivas Murthy
MD
BC Children’s Hospital Research Institute
Trial name Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial (CATCO)
Type of trial Phase II
Trial ID NCT 04330690
Health Canada Status Does not require Health Canada approval
Trial Status Open
Location
Alberta, British Columbia, Ontario, Quebec, Manitoba, Saskatchewan, New Brunswick, Newfoundland and Labrador, Nova Scotia, Prince Edward Island, Yukon, Northwest Territories, Nunavut
Trial description

This study is an adaptive, randomized, open-label, controlled clinical trial.Subjects will be randomized to receive either standard-of-care products or the study medication plus standard of care, while being hospitalized for COVID-19. Lopinavir/ritonavir will be administered 400 mg/100 mg orally (or weight based dose adjustment for children) for a 14-day course, or until discharge from hospital, whichever occurs first

Study team
Nelson Lee
Nelson Lee
MD
University of Alberta Hospital
Allison Mah
Allison Mah
MD
Vancouver General Hospital,
Natasha Press
Natasha Press
MD
St Paul’s Hospital
Shane English
Shane English
MD
The Ottawa Hospital
Robert Fowler
Robert Fowler
MD
Sunnybrook Health Sciences Centre
Bryan Coburn
Bryan Coburn
MD
Toronto Western Hospital
Matthew Cheng
Matthew Cheng
MD
McGill University Health Centre-Glen Site Royal Victoria HospitalRecruiting
Alexis Turgeon
Alexis Turgeon
MD
CHU de Québec – Université LavalRecruiting
Francois Lellouche
Francois Lellouche
MD
Institut Universitaire de Cardiologie et de Pneumologie de Québec- Université LavalRecruiting
Francois Lamontagne
Francois Lamontagne
MD, FRCPC, MSc
Université de Sherbrooke and CIUSSS de l’Estrie – CHUS